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Persistent/Hemorrhagic Anovulatory Follicle

Equine-Reproduction.com Bulletin Board » Breeding Problem Mares - Volume 2 » Persistent/Hemorrhagic Anovulatory Follicle « Previous Next »


Author Message
 

Jennifer Holan
Neonate
Username: Jenzcritters

Post Number: 7
Registered: 05-2012
Posted on Sunday, May 20, 2012 - 06:26 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hi. My mare aborted then cycled into a hemorrhagic anovulatory follicle. My vet recommended micro-dose prostin 3 days in a row starting 7 days after the day the speckles were seen. Today is prostin d3. 3 days ago, the HAF was 72 mm and the other ovary had only tiny follicles. Today, the HAF is 37 mm and the other ovary has 2 18's although the uterine score is only 0-1 at best. Is this a good sign that she is going to respond to the prostin and come into estrus since the HAF has halved in size in 3 days? How long does it usually take for estrus to start in these cases? Should I continue to give daily microdose prostin until she comes into estrus? Thanks. I SO want to get her bred this year!
 

Jos
Board Administrator
Username: Admin

Post Number: 3563
Registered: 10-1999
Posted on Sunday, May 20, 2012 - 09:21 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

If you review the article about AHFs on our website, you will note that about 85% of them develop luteal tissue and will respond to Prostaglandin F. As you are destroying luteal tissue - which is what a CL is made of - the response time is the same as if one was giving Prostaglandin F to cause a mare to return to estrus - in other words, 3-5 days. In the event that she is going to return to estrus and is not in the other 15% of mares that do not develop AHFs with luteal tissue, then 2-3 days of micro dosing with PGF2a is adequate.
 

Jennifer Holan
Neonate
Username: Jenzcritters

Post Number: 8
Registered: 05-2012
Posted on Sunday, May 20, 2012 - 10:01 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thanks.
So... I won't give her any more prostin and will just monitor to see if she comes into estrus. I hope so. Just also wondering if the shrinking of the size of the HAF is a good sign or does that sometimes happen in that bad cohort of 15%?
Jenny
 

Jos
Board Administrator
Username: Admin

Post Number: 3564
Registered: 10-1999
Posted on Sunday, May 20, 2012 - 10:03 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

May be promising, but you'll know for sure in 3-5 days!! :-)
 

Jennifer Holan
Neonate
Username: Jenzcritters

Post Number: 10
Registered: 05-2012
Posted on Thursday, May 24, 2012 - 10:07 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hi. Just an update. I tried the new regimen for HAF. My vet says the paper indicates you give microdose prostin daily for 3-4 days. I did this and it worked! My mare is in estrus and has a 33 follicle. I will ship tomorrow and breed Saturday. Will give HCG too. This is definitely something everyone should try if they get a hemorrhagic anovulatory follicle.
 

Jos
Board Administrator
Username: Admin

Post Number: 3570
Registered: 10-1999
Posted on Friday, May 25, 2012 - 10:50 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Good to hear! It's not a "new" protocol though... :-) The use of microdosing PGF2α has been around for well over 10 years and as I noted above, 85% of AHFs produce luteal tissue and will respond to PGF2α. I think it's only fair to give credit where credit is due:

Alvarenga M.A., Ferreira J.P.C., Meira C., Luna S.P.L., Burns P.J.; (1998) Induction of luteolysis in mares utilizing a micro-dose of prostaglandin F2α in the sacral lumbar space; JEVS 18:3, 167168

Nie G. J., Goodin A.N., Braden T.D., Wenzel J.G.W.; (2001) Luteal and clinical response following administration of dinoprost tromethamine or cloprostenol at standard intramuscular sites or at the lumbosacral acupuncture point in mares; Am J. Vet Research 62;8: 1285-1289


:-)



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