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Pge1 or pge2 to ripen cervix

Equine-Reproduction.com Bulletin Board » Breeding Problem Mares - Volume 2 » Pge1 or pge2 to ripen cervix « Previous Next »


Author Message
 

Peta Oxenbridge
Neonate
Username: Winning_colours

Post Number: 1
Registered: 10-2011
Posted on Tuesday, October 04, 2011 - 07:35 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hi Jos, We are a small TB breeding farm in Australia. I have two mares with compromised cervix's . One has been barren for three years which I bought by mistake!, the other a 17yo) Both mares cervix fail to ripen during oestus and both mares have fluid in uterus. We have used lavages, digital dilation, ecbolics, immunostimualts etc etc. Mares culture, cytology clean and caslicked. I really feel the reason for the fluid is a mechanical problem of the cervix. I have a box of Cytotec (200mg misoprostol tablets) and pge2 dinoprostone (2mg / 3g) gel. Have you any info on administration (dosage and timing etc). And if any effect on the stallion from coitus. Looking forward to any info. Cheers Peta.
 

Jos
Board Administrator
Username: Admin

Post Number: 3416
Registered: 10-1999
Posted on Wednesday, October 05, 2011 - 01:19 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

You might try using estrogen as well - estrogen is the hormone that is responsible for stimulating cervical relaxation and estrus receptivity, and we have seen good success with it's use.

Have you been using the oxytocin protocol? It can make a huge difference when followed to the "t" as well.

Specific to your question, the following protocol has been reported to have success:

Use 200g Misoprostol (the PGE1 analogue misoprostol). Dissolving the tablet in 1 ml of sterile saline (just enough to create a paste) and spread it on the external cervical os. Within a couple of hours, the cervix should be relaxed. Repeat this for 3 consecutive days during estrus, and accompany with a uterine lavage about an hour after treatment. Manually dilate the cervix after the lavage.
 

Peta Oxenbridge
Neonate
Username: Winning_colours

Post Number: 2
Registered: 10-2011
Posted on Wednesday, October 05, 2011 - 04:56 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thanks very much. Will let you know how I go in due course.

Yes, I used the oxytocin protocol religiously (just got in another six bottles!) which has worked marvelously in other problem breeders however not resolved fluid for these particular mares. Feeling their cervix gave me insight that I need to try a different approach.



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