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Lasix to help with uterine pooling?

Equine-Reproduction.com Bulletin Board » Breeding Problem Mares - Volume 2 » Lasix to help with uterine pooling? « Previous Next »


Author Message
 

Carol
Yearling
Username: Rodawn

Post Number: 99
Registered: 05-2009
Posted on Saturday, June 26, 2010 - 05:36 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Jos and/or Kathy, I sure could use your opinion on this question.

She is an extremely well-bred Hanoverian mare, which is why I persist, despite her uterus difficulties. She pools fluid in her uterus. We use the oxytocin protocol on her before being bred, and then after breeding, saline flushing and Oxytocin for 2-3 days. From that point onwards, she begins to accumulate fluid again. As a result, the embryo tends to drown, as-it-were, before it can attach to the uterine wall. If we can manage to get the embryo to attach to the uterine wall then she maintains the pregnancy to term and follows through with easy deliveries and excels at motherhood.

It was suggested to me by another breeder that perhaps the mare could be put on Lasix because of its powerful diuretic abilities. Would Lasix actually help reduce uterine pooling... or would the increased urine output (from the diuresing effect) actually risk increasing the fluid? The fluid has only once tested positive for E. coli and one other bugly bacterium, whose name escapes me at the moment, which cleared up with a course of systemic antibiotics plus uterine lavage. Then she was bred next cycle and had an uneventful pregnancy. Otherwise, her fluid just seems to be sterile fluid.

She has a Caslicks in place but as she ages she has become quite vulvar tilted.

Thoughts on this problem?
 

Jos
Board Administrator
Username: Admin

Post Number: 2921
Registered: 10-1999
Posted on Tuesday, June 29, 2010 - 10:12 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I am not aware of Lasix having proven useful in reduction of uterine fluid. Probably a better medium would be estradiol cypionate, which will stimulate uterine blood flow and (hopefully) assist with lymphatic drainage. I would also be religious in the use of the oxytocin protocol every 4-6 hours until 3½ days after ovulation. Then about 4 or 5 days after ovulation you could give her some more estrogen.

Note that the embryo does not attach to the uterine wall. While it becomes "fixed" in the uterus at about 16 days, placental attachment (i.e. formation) does not commence until about 40 days after ovulation at which time it has become a fetus.
 

Carol
Yearling
Username: Rodawn

Post Number: 100
Registered: 05-2009
Posted on Wednesday, June 30, 2010 - 11:34 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hi Jos, thanks for the advice.... I will definitely try the EC.

Also, thanks for the terminology correction - it's what I meant, but stated incorrectly. :-)



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