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Cytology results

Equine-Reproduction.com Bulletin Board » Breeding Problem Mares - Volume 2 » Cytology results « Previous Next »


Author Message
 

Joe
Neonate
Username: Danbo

Post Number: 1
Registered: 07-2009
Posted on Wednesday, July 22, 2009 - 01:31 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hello, Just received the results of a culture and cytology and wondered if anyone can interpret it for me into layman's terms. The culture came back negative. Here is the cytology report:
"Source: Uterine cytology
DESCRIPTION:
The sample is highly-cellular and contains individualized and clustered cells that are often degenerate. Intact cells have rounded to ovoid nuclei with coarsely condensed chromatin and a small to moderate amount of basophilic cytoplasm. The degenerate cells appear to have indistinct vacuoles within their cytoplasm. The background contains abundant nuclear material.
MIRCROSCOPIC FINDINGS: NUMEROUS DEGENERATE CELLS, WITH A FEW CYTOLOGICALLY UNREMARKABLE EPITHELIAL CELLS.
COMMENTS:
Low numbers of intact epithelial cells appear cytologically unremarkable. There are numerous ruptured cells, therefore the possibility that there is inflammation is still present. Additionally, some of the cells appear to have vacuoles that were indistinct which could indicate either a dysplastic change in other ipithelial cells or possibly the presence of macrophages. Resampling, or biopsy with histopathology, and possible culture with sensitivity are recommended to further evaluate the uterus."
Thanks in advance for any input,
Joe
 

Jos
Board Administrator
Username: Admin

Post Number: 2564
Registered: 10-1999
Posted on Thursday, July 30, 2009 - 12:38 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

The basic description of the cells references normal cells but with many that are degrading. This degradation may be as a result of damage during collection or transit to evaluation, or because of an issue in the uterus. I believe you will find that is why resampling is recommended (i.e. there is no definitive result). The suggestion of the possible presence of macrophages suggests a possibility of a chronic inflammatory situation (i.e. having been present for a long time - an acute situation would be more likely to have neutrophilic presence).

If it were me, I would follow the advice given and re-evaluate with a culture and sensitivity as well, or even better have a biopsy and culture (and sensitivity) performed.



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