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Regumate, any alternative?

Equine-Reproduction.com Bulletin Board » Breeding Problem Mares - Volume 2 » Regumate, any alternative? « Previous Next »


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Ad TB
Breeding Stock
Username: Ajvtbs

Post Number: 829
Registered: 01-2009
Posted on Wednesday, May 27, 2009 - 07:22 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I have a 16 year old thoroughbred mare that's 17 days in foal. The vet has recommended starting her on Regumate because she aborted last year and we were having big problems getting her covered because she had a lot of fluid. She was finally covered 16 days ago and with the help of oxytocin has no fluid before or after covering.
She's due to be on Regumate until 120 days. The problem I now face is she's turned out full time and is very difficult to catch, she has never been easy but is now a nightmare probably as a result of being prodded so many times when she was fluidy with oxytocin. It took us an hour to catch her this evening and today was only day one of her regumate. She is not a straightforward mare, she's blind in one eye and is very nervous, she weaves and box walks. She does not tolerate being separated from other mares for any length of time. I'm wondering if there is any other form of progesterone that can be used to maintain pregnancy that does not have to be given daily. Is there any injectable form that can be given every few weeks or any implant?
My boyfriend is an equine reproductive vet and he is looking into a form of injectable progesterone that he used when working as a vet in Australia, it was given every 10 days.
Anyone have any other ideas?
 

Jan Owen
Senior Stallion or Mare
Username: 1frosty1

Post Number: 2464
Registered: 04-2006
Posted on Wednesday, May 27, 2009 - 07:28 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I know my mare figured out pretty quikly that the bucket held goodies along with her regumate and came a running...

I am glad to hear that she is safely 17 days in foal...I know this has been a challenge for you!
 

Jos
Board Administrator
Username: Admin

Post Number: 2460
Registered: 10-1999
Posted on Wednesday, May 27, 2009 - 11:24 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

First I would suggest reading the article on this site entitled "Does my mare need Regumate". It should prove entertaining reading for you if nothing else.

Then, presuming you still feel the need for progestin supplementation even though you will have just read that it is the most over-used drug in equine reproduction, you might consider using the long-acting injectable altrenogest (the same drug that is in Regumate) available from BET Pharmacy, which comes in a 30-day formulation - i.e. one shot and you're good for 30 days.
 

Ad TB
Breeding Stock
Username: Ajvtbs

Post Number: 833
Registered: 01-2009
Posted on Thursday, May 28, 2009 - 05:20 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I have read the article and found it very informative. This mare is on Regumate because she is an older mare, has had 9 previous foals, has poor uterine clearance and is prone to fluid and most importantly she is a valuable mare, carrying a pregnancy by a very valuable stallion and aborted last year. The pregnancy is worth tens of thousands possibly even in the region of a hundred thousand euro to me. The vet that recommended Regumate worked with Angus McKinnon for five years and is using McKinnon's protocol for mares that warrent Regumate. He said without a doubt McKinnon would have the mare on Regumate. We do not put our mares routinely on Regumate in fact this is the only mare this year that it is being used on out of 7 in foal.

Unfortunately long-acting injectable altenogest is not available or licenced in Europe. This evening we spent 2 hours trying to catch the mare to no avail, she galloped and galloped and wouldn't let us within 50 metres of her so she got no regumate tonight.

Has Jos or anybody else had any experience with the use of a PRID in pregnant mares. It seems like an ideal solution to the problem the only concern that I have is that it often causes an inflammatory response in the vagina, resulting in discharge and pus and I'm afraid that this could result in an ascending placentitis. Any ideas? I'm at a loss.
 

Kathee McGuire
Senior Stallion or Mare
Username: Katheekj

Post Number: 1484
Registered: 12-2005
Posted on Thursday, May 28, 2009 - 07:59 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Anyway to create a smaller field for her temporarily? Maybe something she and a buddy could stay in together? Maybe even something with a yet a smaller area inside to herd her into.
 

Jos
Board Administrator
Username: Admin

Post Number: 2464
Registered: 10-1999
Posted on Friday, May 29, 2009 - 12:13 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

As you will have noted in the article, there are specific areas where progestin supplementation is warranted. One thing I do want to clear up though is that progestin therapy tends to exacerbate uterine fluid conditions, as it tends to reduce the ability of the uterus to absorb fluids... just a point to consider.

I have not had experience with PRID's and pregnant mares (actually PRID's are still fairly new and not widely used in the USA), but would also have concerns about the vaginitis and cervicitis that has been noted as associated with their use... the last thing I would want to be doing with a "problem" mare who has precarious pregnancies would be to irritate that particular portion of her anatomy! I don't really have any other suggestions off the top of my head... :-(
 

Ad TB
Breeding Stock
Username: Ajvtbs

Post Number: 836
Registered: 01-2009
Posted on Friday, May 29, 2009 - 05:56 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thanks Jos, I think the risk of a vaginitis and an ascending placentitis is too great for me to use a PRID. I do know of some big studs that use them with success but I'm not willing to risk it.

On a more positive note I did manage to catch the mare this evening with a lot of time a patience.

Kathee, she's in a 5 acre paddock which is the smallest I have on the farm. She's out with two other mares that also don't have foals, she was in a small all-weather paddock prior to this and if she doesn't want to be caught she doesn't want to be caught. She'll gallop straight over me and she is fast, she wasn't a great racehorse for no reason. She'd also run straight through wire or a fence if cornered!! Yes she is difficult but I have a massive soft spot for her, she's unique!!



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