I'm hoping JOS sees this one, she seems to have all the answers and boy do I need them! 18 yo mare, tried three times last year AI, very fertile stallion, no luck. 3 this year. I got a hold of a theriologist (sp?) who gave me some hope. We tried and the mare never ovulated. Mare has had 4 foals, last in '05 with a single insemination. She is a 2A, nothing too weird for being 18. She developes fluid and we always mangage it with flushing/oxytosin/desarelin (sp?). Had a hemoragic last year that we ended on, and this year on first cycle. Second was normal, no conception. Did it all again and now the folicle is regressing. Used desarilan, HCG, estramate. Have tried Settle in the past. Have tried Regumate in the past. Now she seems to not be "firing" correctly. I saw your posting on the P & E shot, which the specialist rx'ed. Will this work on her? She is a great mare in very good physical and mental condition. She is turned out and ridden both. Very happy, not stressed at all. Cultures are negative for anything past two years. If I can tell you more let me know. I want a foal!
A mare in this age group and parental status is a high-risk candidate for delayed uterine clearance, and would likely benefit from following an entire oxytocin protocol. If you have not been using multiple doses a day as described in that article, you may want to discuss doing so with your veterinarian.
About 10% of cycles involve AHF's, so nothing unusual there.
P&E is designed to produce a timely estrus and ovulation, nothing more (follow that article for details), which doesn't sound much like the issue here.
What has the cytology shown?
The other thing to consider as a possibility, although rare, is stallion/mare incompatibility. If you were to try a different stallion and get an immediate pregnancy, that might be an issue worth considering.
Jos, The cytology showed, I hope I have this right, an inflamation in certain parts of the uterus. She has had abnormally long cycles left to her own timing this year. Only when we induce the cycle does it go about 21 days. That is why the specialist rx'ed the P & E shot. BUT she just prescribed a single shot??? She explained that it would "reboot" her cycle, hopefully to normal but could cause more fluid. We did multiple oxytocin shots on all the cycles, it worked on the fluid but no pregnancy. How about the DMSO flushing? I've heard about it from several places now. Thanks!!!
Whoops, I forgot the last question. The stallion we are using this time is a half brother to the one in '05. I really like him and I'm inclinded not to switch because I've heard over and over that incompatability is very low. Knowing my track record, it most likely is the problem I'm not going to semen shop again this year. So unless someone gives me hope I'm done for a year and will redress it in the Spring.
If the cytology is showing inflammatory response in the uterus, you need to find out what the causative against is and deal with that before moving on to other issues... Endometritis is the leading cause of pregnancy [establishment] failure.
How are you determining the "abnormally long cycles"? Are you ultrasounding to determine ovulation and inter-ovulatory period? If not, then you may not be seeing an accurate picture.
All the P&E is going to do in the situation of use that you describe is give you a more-or-less known starting point (which really isn't particularly useful if you're monitoring the cycles well). It won't do anything other than that. If you're not breeding on the P&E-induced estrus, then the possibility of mid-cycle follicles and irregularity will reappear once the P&E treatment period ends (i.e. with the ovulation on that estrus).
How much in the way of "multiple oxytocin shots" have you used previously? Sometimes not enough are used each day - our protocol calls for every 6 hours, and what you are describing sounds very much like a mare with delayed uterine clearance issues.
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