Hello! I was wondering if anyone has had a problem with mares getting a local reaction at the site of the P & E injections. I am trying it on my own mare prior to recommending it to my clients & my mare is getting local swelling at the site of every injection & is quite sore. The P & E (from Bet Pharm) is being drawn up aseptically on a daily basis. I am rotating injection sites, but am running out of good places (I am on day 5). I am treating them with hot compresses. This is a chestnut mare who tends to be reactive to things like fly bites, etc., so I don't kow if it is just her, or a common reaction. Would 2 separate injections of the P4 & the estrogen work better, or is the carrier the same? Perhaps in the future, I might try the oral form with this mare. I don't want to quit now though, because I am dodging the stallion's show schedule & we are late in the season. Any suggestion would be helpful. I am using a 22g, 1 in. needle. I found that the P & E wouldn't go through the insulin needle, as had been suggested. Thanks, Muffy
Use locations below the mid-line if you are not already doing so. These will include the chest muscles and the thigh below the point of rump.
You should be using at the smallest a 20 x 1½ needle, and preferably an 18 x 1½ gauge. I'm not sure who recommended the insulin syringe - but that most decidedly won't work! We use insulin syringes for oxytocin and prostaglandin, but they are small molecule drugs, P&E and the cottonseed oil carrier are not! If you get the drug deeper in the muscle, you will probably see less of a reaction (I can't imagine how hard it is to get it to go through a 22 gauge needle!!! )
We don't particularly recommend the oral product, as the products compounded in the US to date have not shown good reliability at timely estrus induction and ovulation pinpointing.
Please note that opinions, product information, advice or suggestions posted on this bulletin board are not necessarily those of the management at Equine-Reproduction.com nor does the maintenance of the post position indicate an implicit or any endorsement of that information, opinion or product.
Further, although we have the greatest respect for the posters offering assistance here, you are advised to seek a consultation with your veterinarian prior to using information obtained from this board if it is of a veterinary nature.Proud to be sponsored and supported by:
) 
