Jos (or anyone else) - have you heard of using ECP (estradiol cypionate) in stallions instead of Regu-Mate to control unwanted sexual behavior? I've come across anecdotal evidence of it being used for upward fixation of stifles, but only one research article that claims that long-term administration did not seem to affect daily sperm output or total sperm numbers. However, testosterone was higher in the ECP-treated horses versus the control group, both before and during ECP treatment. So if testosterone was elevated, I wouldn't think this would be indicated to give a stallion to control sexual behavior (as has been recommended to us)? I'm totally confused! An light you may be able to shed on this would be greatly appreciated.
Thompson et. al. indicated elevated Testosterone in treated geldings (which may be the research you are citing), which would certainly suggest to me that one is less likely to see a quietened behaviour pattern. I'd also be skeptical about not having an impact on sperm production, as there's a pretty sensitive negative feedback loop on testosterone that also affects FSH which in the stallion relates to sperm production. I'd have to look more closely at the specific paths affected in that situation though, but without doing so, I wouldn't be really comfortable using estrogen...
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