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Domperidone and Chorulon for milk production.

Equine-Reproduction.com Bulletin Board » Hormonal Manipulation » Domperidone and Chorulon for milk production. « Previous Next »


Author Message
 

Lisa Weir
Yearling
Username: Pals_pal

Post Number: 83
Registered: 08-2005
Posted on Wednesday, November 23, 2005 - 08:53 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

We've just used this treatment for a mare with a very hungry little foal. It seems to have worked and baby is now gaining weight and is much more energetic?

I was just wondering if anyone else has experience with this and if anyone knows why it works?
 

L Detweiler
Neonate
Username: Msfarab

Post Number: 1
Registered: 01-2006
Posted on Saturday, January 28, 2006 - 04:34 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Please describe the method you used? How many doses, & when ( time periods) were they given?
When did you start using it, and why ? Was it readily available or did you have to wait for it to be ordered in ?


We used it before... 2 tubes on one mare, and not much help with her foal, as we ended up supplementing the foal and the foal was obviously hungry. No fescue in field as she was dry lotted for the last stages of pregnancy and hay had none in it.
msfarab
 

Heather Kutyba
Weanling
Username: Heatherck11

Post Number: 34
Registered: 01-2006
Posted on Saturday, January 28, 2006 - 10:39 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I am currently using Domperidone in my mare. We started using it because her lactation reduced when she impacted/colicked post-foaling.
The repro specialist/neonatologist has instructed me to give 5-10 cc's once daily. We began with 5, and have seen some improvement. Mostly, the foal is no longer frantically trying to nurse constantly.
My understanding is that you have to use it for 2-3 weeks.
Like you, there is no fescue where my mare is. She impacted a few days after foaling, stressing her enough to reduce her milk production...resulting in a very unhappy foal. We are also using Mares Match milk replacer twice daily for the foal.
The domperidone is a very special order medication. I work for a veterinarian, and couldn't get it immediately. It can only be made by a compounding pharmacy. Domperidone is not carried by any major pharmaceutical company in the US, and it is only to be used "off label", as it is not an approved drug.
The only compounding pharmacy that I could find that does compound it is WEDGEWOOD PHARMACY...fortunately, the neonatologist I use had a few tubes on hand.
 

Lisa Weir
Breeding Stock
Username: Pals_pal

Post Number: 123
Registered: 08-2005
Posted on Tuesday, January 31, 2006 - 05:34 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

The mare we used it for just seemed to not produce enough for the foal to grow. He was always nursing for short periods and needed to suck for a while before having to swallow. He was about two weeks old when we noticed that he wasn't doing as well as he should be.

The mare was given one tube of Domperidone daily for 5 days and a half dose of Chorulon daily for 2. These were both available immediately when we spoke to the vet about our problem. I was under the impression that it was the combination of the two drugs that worked and one on it's own was not effective?

We noticed bubby feeding better by the third day and stopped tubing him a couple of days later. (He wouldn't accept a bottle and was too young to eat a feed) He's never looked back.

I'm in Australia and I assume that domperidone is readily available here, although I had never seen it used before. I can't remember which company made it.
 

Jos
Board Administrator
Username: Jos

Post Number: 10435
Registered: 10-1999
Posted on Tuesday, January 31, 2006 - 10:55 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Domperidone is a dopamine antagonist, which stimulates prolactin secretion and hence milk production.

I'm unsure of the purpose of hCG in this combination, as I am not familiar with it's use in induction of lactation - I will go and review some literature and see if I can find a reference to it, or perhaps if you can, could you provide me with a reference as I would be interested in looking at it.
 

Lisa Weir
Breeding Stock
Username: Pals_pal

Post Number: 130
Registered: 08-2005
Posted on Wednesday, February 01, 2006 - 06:28 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hi Jos,
I'm told by the vet who prescribed the treatment that she had been taught it by another vet who has had excellent results. Apparently trials are being conducted now. I'll see if I can get some info for you.

As for finding references to these things...I usually look here first.

All the sights I find that look interesting require registration by a vet.
 

Jos
Board Administrator
Username: Jos

Post Number: 10438
Registered: 10-1999
Posted on Wednesday, February 01, 2006 - 02:41 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thanks Lisa! If you do get more details (such as a research paper even) I'd love to have them, so if it's too big to paste here, you could e-mail me via our contact page.

Thanks! :-)



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