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Too much HcG in a day?

Equine-Reproduction.com Bulletin Board » Hormonal Manipulation » Too much HcG in a day? « Previous Next »


Author Message
 

Kristen B.
Nursing Foal
Username: Kristen_b

Post Number: 12
Registered: 06-2010
Posted on Tuesday, March 22, 2011 - 10:39 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

OK, I know more than 2500 iu of HcG can postpone ovulation. I think my vet gave 2500 iu two days in a row, within 24 hours of each other... She didn't ovulate for several more days and the follicle really stalled, is this why? Should only one dose of 2500 iu be given per cycle, or is it OK to give several of these doses per cycle?
 

Jos
Board Administrator
Username: Admin

Post Number: 3165
Registered: 10-1999
Posted on Tuesday, March 22, 2011 - 11:40 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

5,000 IU is the excess threshold most commonly considered to be avoided.

Having said that, recent research indicates that doses of as low as 750 IU are adequate to promote ovulation at the same rate as 3,000 IU.

As far as 5,000 IU causing a delay in ovulation - it is possible, but you should also consider the time of year, which is very much "transitional phase" where you are more likely to see prolonged estrus and a slower proceeding to ovulation.
 

Kristen B.
Nursing Foal
Username: Kristen_b

Post Number: 13
Registered: 06-2010
Posted on Wednesday, March 23, 2011 - 10:06 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thanks Jos! This was last year when we tried to breed this mare and I'm just getting all my ducks in a row for this breeding season. I'm really trying to convince him to use Histrelin (he's not convinced yet!)

So just to be clear, just one does is needed, not one dose several days in a row? He gives the same dose every time he breeds. So, if we had a shipment 4 days in a row, he would give 4 days in a row. Which would end up being 10,000 iu over 4 days' time.

I just have a bad feeling that we bred over and over, trying to get her to ovulate but the HcG actually prolonged ovulation and then her uterus was offended by repeated breedings and that's why she stayed open all year?!



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