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Regumate - from daily to biorelease

Equine-Reproduction.com Bulletin Board » Hormonal Manipulation » Regumate - from daily to biorelease « Previous Next »


Author Message
 

Den
Neonate
Username: Wdh009

Post Number: 7
Registered: 06-2007
Posted on Tuesday, September 15, 2009 - 03:34 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hi,
My mare is receiving daily oral Regumate while at the breeding farm. She will be coming home at around day 60 of her pregnancy. The daily will be problematic at home, therefore, I am investigating the option of switching over to the biorelease 12-day injectable.
Is this the correct product from BET?:

BioRelease Altrenogest LA 150 mg/mL, 1.5 mL/IM dose,11 mL (7 dose vial) 12 day treatment

If I opt to keep her on this until around day 150, I would probably need the above-cited 7 dose vial to extend the additional 90 days once she's home.

I realize my vet needs to order this, but can someone tell me what this would cost? What about the cost of the 20-dose vial?
Also, I've read talk, in some threads, about the need to "wean" the mare off of this. Is there a procedure to this, or would her last 12-day injection just be her last dose?

Thank you,
Den
 

Jos
Board Administrator
Username: Admin

Post Number: 2624
Registered: 10-1999
Posted on Tuesday, September 15, 2009 - 03:53 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

If you are planning on keeping the mare on the supplementation until 150 days, then I would recommend using this formulation from BET Pharmacy:

BioRelease Altrenogest Microparticles LA 30 day treatment; (Single dose vial + suspending vehicle) Altrenogest 500 mg for I.M. Injection

As you can see, this requires dosing only every 30 days.

I cannot tell you the exact price, in part because that will depend upon what a veterinarian puts on as a "mark up", but we generally find that it will cost about the same as Regumate would for the same treatment period.

as far as "weaning" is concerned, it is difficult to reduce dosage of the biorelease/microparticle products, because by design they release the same dosage each day. The only thing would be that if you gave a half dose as the last dose, then the duration of release would probably be reduced. If you are stopping treatment after 150 days (indeed, probably after 120 days) then the chances are that the mode of cessation will be academic, as there are other sources of progestins being released within the mare anyway.

Note that all the time-release products may have an increased tendency for local site reaction (swelling). Don't be alarmed if you see it! We typically give the shots in the pectoral muscle, which allows for drainage more easily than other sites, and less chance of a sterile abscess. Giving it in the neck or rump is not recommended.
 

Den
Neonate
Username: Wdh009

Post Number: 8
Registered: 06-2007
Posted on Tuesday, September 15, 2009 - 04:13 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Jos, thanks much for your quick response! I will see if BET will provide me with prices on these (not including the markup).

Den
 

Jos
Board Administrator
Username: Admin

Post Number: 2625
Registered: 10-1999
Posted on Tuesday, September 15, 2009 - 06:34 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

FWIW, typically they will provide pricing only to the veterinarian.
 

Den
Neonate
Username: Wdh009

Post Number: 9
Registered: 06-2007
Posted on Wednesday, September 16, 2009 - 12:48 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

You are correct! I didn't see your post until afterward, but I sent an online inquiry via their website. I asked about pricing and about their thoughts on weaning a mare off of the product. They wouldn't answer either question, and kindly told me to have my vet call.
Den



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