I have just logged on following a web search re PG v. laminitis and saw the chat from Terri Berwanger in Aug 2006. I have just collected a brood mare from a renowned AI centre. Mare 14 yrs. never been AI before (just natural covering with immediate success). Went thru several procedures including PG and now back with laminitis - which she has never had - and NOT in foal. has anyone else had this experience? thoughts please. They even PGd her when laminitis had been confirmed. thanks
Prostaglandin is released by the uterus during the mare's own estrous cycle - that release is what allows her to come back into estrus ("heat"). It would therefore be unlikely for prostaglandins to cause laminitis, as if they did, all mares would be suffering from it! I am not aware of any literature that demonstrates a link between Prostaglandin F2α use and laminitis in mares.
I know PG is released "naturally" however the actual amount released into the system obviously has some bearing on this matter. Some web research I have done states "increased circulating concentrations of inflammatory mediators, such as PGF 2a may lead to venoconstriction within the laminar tissue and predispose the horse to the development of laminitis". Based on current studies equine laminar veins are exquisitely sensitive to PFG 2a . I can only go on what I read and that a top brood mare of mine with NO signs of laminitis at any time, even during her previous pregnancies, has now come back with laminitis. Another "paper" states "one of the predisposing factors of laminitis is "the release of prostaglandin". anyone else heard of this reaction?
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