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Regumate and fluid retention

Equine-Reproduction.com Bulletin Board » Hormonal Manipulation » Regumate and fluid retention « Previous Next »


Author Message
 

Linnea Pärnaste
Neonate
Username: Beti45

Post Number: 1
Registered: 07-2008
Posted on Friday, July 25, 2008 - 06:04 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

We have a 6 y old SF mare, whom we have been trying to breed for the past years. Never has been pregnant or had any foals. Now, we put her on Regumate on day 3 post ovulation. Checked her at day 14, and the vet is not sure what she saw. There was fluid present, but she was not sure if there is a baby. She decided to check the mare again at day 16. In case of fluids, and provided there still is a pregnancy, would it be necessary to quit Regumate program? Sorry for asking this..
 

Jos
Board Administrator
Username: Admin

Post Number: 2105
Registered: 10-1999
Posted on Saturday, July 26, 2008 - 06:21 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

If there is fluid present in the uterus, the pregnancy is probably already threatened. Progestins (of which Regumate is one) will tend to suppress the uterus' ability to absorb fluid, so you may have created that problem by putting her on it, or exacerbated it by prematurely closing the cervix.

Catch-22. If you don't take the mare off the Regumate, then the fluid issue may persist and threaten the pregnancy; if you do take her off the Regumate, then the cervix may relax and the pregnancy be lost.

All you can do is check again and see what's happening, but I'm guessing it's a pretty fair bet that there won't be a pregnancy... :-(
 

Linnea Pärnaste
Neonate
Username: Beti45

Post Number: 2
Registered: 07-2008
Posted on Sunday, July 27, 2008 - 07:51 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Dear Jos, thank You so much for Your comment. The reason, why we decided on Regumate in the first place was something we detected this year. After ovulation, CL starts to form, but after 48 hours it is already hard to detect, dissapearing completely afterwards. This year we had 2 cycles with cervix closed during ovulation, on 3 occasions we had to state a fact that we had missed an ovulation, as when her 2 or even 3 major follicles were developing ( over 4 cm each), the one actually ovluating was something small and "unregistered"... CL problem, checked for postive on every occasion. In conclusion, not the easiest mare to breed:-) However, in case there is no pregnancy this time, we shall try once more this year. Now, also following Your recommended oxytocin protocol. Still, there is question of that CL...
 

Jos
Board Administrator
Username: Admin

Post Number: 2108
Registered: 10-1999
Posted on Sunday, July 27, 2008 - 09:11 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Run a blood-progesterone assay series to determine CL presence/function. The fact that you have had an open/closed cervix suggests no problem, as it's progesterone that closes the cervix, and the progesterone comes from the CL.
 

Linnea Pärnaste
Neonate
Username: Beti45

Post Number: 3
Registered: 07-2008
Posted on Monday, July 28, 2008 - 08:01 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Dear Jos, thank You for that information. I really did not know that. Just checked the mare in question, after we quit Regumate 2 days ago. Much less fluid (only a little left), and a surprise: we found a perfectly nice conceptus in it. Being realistic here: I am aware that we can loose it just as easily, and if that happens I shall follow Your regime. Thank You again, You have been such a great help:-)



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