If you're breeding a maiden mare and don't know how her system will react to AI and prostaglandin, should you ask the stallion station to follow up inseminating her by seven days of oxytocin shots to keep fluid out of her uterus?? (Since you wouldn't know in advance that she's likely to need the assistance of the oxytocin to clear any intrauterine fluid?) I've read your article on oxytocin but can't be sure whether you advise its administration w/maiden mares or just older mares w/a history of fluid retention, etc.)
Unless you were breeding a mare three and a half days prior to ovulation, you would not use seven days of oxytocin! The latest that the oxytocin should be used is three and a half days after ovulation.
OK - now we've got that out of the way, let's look a little closer at your questions...
There is no reason to assume that a mare will react differently to AI than live cover. All mares have a post-breeding inflammatory response, and a young, reproductively sound mare should clear the fluid produced by that inflammatory response with no trouble. Oxytocin therefore is probably not needed. If the mare were an older mare - especially an older maiden mare - then the oxytocin may well play a valuable part in assisting that fluid clearance. A lot will depend upon what the pre- and post-breeding veterinary evaluations show. If there is fluid present, then yes, oxytocin is going to be of value. If no fluid is present, then although it is unlikely to do harm, it may not be beneficial either.
I am a little unclear what you are referring to by not knowing how the mare will react to prostaglandin. Any reaction to the prostaglandin is unlikely to influence the outcome of the breeding (unless of course it is not given at the right time to bring her into estrus!), and oxytocin treatment will not impact the effects of the prostaglandin anyway.
If you are referring to the not uncommon side effects of prostaglandin use (sweating and cramping), these are usually transient effects that will not last. You can actually avoid these side effects while still bringing the mare into "heat" (again assuming suitable timing) by using 1/10th of the normal dose two days in a row. This means that you would be typically giving (for a 1,000 lb mare) 0.1 (zero point one) ml to 0.2 (zero point two) mls of the prostaglandin two days in a row. The mare should come into estrus in the same time frame as with the full dosage, but with none of the unpleasant side effects. Note that there are reasons for prostaglandin not bringing mares into estrus as anticipated, and we deal with those in an article on this site about prostaglandin use.
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