After two years of trying to breed a mare with poor uterine clearance, numerous infections and a class 2B uterus we finally have a pregnancy!
She has been on 10ml regumate once a day since ovulation. At day 19, the vet checked her progesterone level and found it to be inadequate at 1.2. He has said to increase her daily dose of regumate to 20ml.
Is it alright to give this now 'double dose' just once a day, or is it better to give 10ml twice a day or at 12 hour intervals? I'm thinking a twice a day dose would sustain a more even level of the hormone, of course it would be easier to give it just once a day...
Liz H Posted From: 22.214.171.124
Posted on Monday, August 30, 2004 - 04:56 pm:
Regumate does not and will not affect the natural Progesterone levels as shown in a progesterone level test .. so I am not sure why the vet is increasing her dose based on the low blood level...
The low blood level just means you need to keep her on the regumate..
That is my understanding.. I could be wrong but I was told by my vet that Regumate will not affect the blood level of Natural progesterone...
Is the mare showing other signs of losing the fetus?
Anonymous Posted From: 126.96.36.199
Posted on Tuesday, August 31, 2004 - 04:12 pm:
I'm aware that Regumate does not effect the 'natural' progesterone levels in the mare;
I am not questioning the reasoning behind the increase; I am only wondering if it's more effective to administer smaller doses at regular intervals rather than one big 'swig' per day...
FWIW - as this thread is almost a year old, so the foal may be on the ground by now - Liz has made a very valid point.
As Regumate does not affect the blood progesterone assay results (except that one can argue it may lower them, as mares on Regumate tend to produce less progesterone themselves), and as the mare is already receiving what has been determined to be an adequate dosage of Regumate to maintain a pregnancy in an ovariectomised mare (note that there is no research that supports it's use in so-called "low progesterone mares"), why is it felt necessary to increase the dosage? She would appear to be receiving an adequate dose already...
If one is going to give a double dose, then yes, giving it morning and night would probably give a more stable level, but as it generally reamins in the system for +/- 24 hours, it's probably academic, as once you've dosed a complete day, the levels will be roughly the same whether the mare receives it once or twice a day. And it's perfectly natural for mares hormone levels to fluctuate during the day, and even from day to day.
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