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Follicle size question in ET mares... Jos, please help!

Equine-Reproduction.com Bulletin Board » Embryo Transfer » Follicle size question in ET mares... Jos, please help! « Previous Next »


Author Message
 

Heidi Caldwell
Neonate
Username: Heidicald

Post Number: 1
Registered: 10-2007
Posted on Monday, May 18, 2009 - 09:00 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I have a teenage dutch mare that I am doing an ET on. The recipient carrier is my other wb mare a year younger at age 16. They both were checked at the university about 3 weeks ago, vet had me start them a week later (May 1) both mares on Regumate for 13 days, and on May 13 and May 14, both mares each got a shot of Lutalize from my vet at home. Each about .5ml. So, two days in a row of that shot. Then they were off everything from last thursday till today. I took them back to university today to check follicle size and leave them there for breeding hopefully end of this week and for him to monitor my recipient mare's follicle and ovulation. The ultrasound today showed my donor mare's follicle at about 2.5 and the recipient was much bigger at 3.76. Vet said that was not so good, he wanted them of course to be right together on this. He said not to give up hope, maybe donor would go earlier and recipient possible hold out a bit before ovulating and I think there is something chemically he was going to do to aid that process. He said if this does not work, we will start again about 5 days after they both ovulate. Jos, can you elaborate on this for me and tell me what my chances are of it actually working on THIS cycle with these follicles way off? I guess he will try to speed up donor ovulation (even on a smaller follicle) and slow down the other one? He did say the bigger follicle was at least still very firm, not to give up hope. I have not ordered the chilled semen yet of course, but am trying to give them updates as I get them.

What is the protocol to get them cycling together again if this does not work out this week? Thanks for any info you can give me.
 

Jos
Board Administrator
Username: Admin

Post Number: 2435
Registered: 10-1999
Posted on Wednesday, May 20, 2009 - 12:43 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

That's the problem with using daily Regumate treatment to attempt synchronicity. It's not reliable.

We use either P&E or the new single shot biorelease altrenogest from BET Pharmacy, either of which gives a better control than Regumate.

There are some possible options, as far as slowing down the donor, giving her estrogen or a progestin may slow down ovulation, while not giving her an ovulatory promoter (such as hCG), and then giving the recipient mare biorelease deslorelin (also from BET pharmacy) once her follicle reaches a 30 mm diameter may help.
 

Heidi Caldwell
Neonate
Username: Heidicald

Post Number: 2
Registered: 10-2007
Posted on Wednesday, May 20, 2009 - 05:16 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thanks, Jos!

I didn't know that Regumate was not the way to go, that is what my vet prescribed so I did it as he said. I got an update today, recipient is at 4.4 but still has not ovu'd, donor is at 3.2. Any chance you think this still may work this cycle? I do think he have donor a speed up shot (desorilyn maybe)

Can you tell me the protocol or send me a link to it to try the new biorelease altrenogest shot to short cycle these two and try again asap if it does not work this round? Assuming Recip ovulates tonite/tomorrow and the other mare a day or so later?
 

Jos
Board Administrator
Username: Admin

Post Number: 2439
Registered: 10-1999
Posted on Wednesday, May 20, 2009 - 07:26 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Go to BET Labs web site, then "Enter USA" > "Equine" > "Protocol for Synchronization of Mares".

It does sound though, if your donor mare has received Deslorelin, and the recip. mare is left alone as though it all might line up yet.
 

Heidi Caldwell
Neonate
Username: Heidicald

Post Number: 3
Registered: 10-2007
Posted on Wednesday, May 20, 2009 - 07:51 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thanks, very helpful!!!
 

Heidi Caldwell
Neonate
Username: Heidicald

Post Number: 4
Registered: 10-2007
Posted on Thursday, May 21, 2009 - 10:02 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Jos, is it a bad idea to do an ET if the donor ovulates and is bred about 24 hrs after the recip ovul's? That has NOT happened in my case but I want to know the scenario if recip ovu's tomorrow before donor. Thanks!!!
 

Jos
Board Administrator
Username: Admin

Post Number: 2441
Registered: 10-1999
Posted on Friday, May 22, 2009 - 12:43 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

The recommended time frame for donor/mare synchronicity is that the recipient mare ovulates between 1 day before and 3 days after the donor mare. So the above scenario is within the standard parameters, although it is more preferable for the recipient mare to ovulate ~2 days after the donor mare.
 

Heidi Caldwell
Neonate
Username: Heidicald

Post Number: 5
Registered: 10-2007
Posted on Friday, May 22, 2009 - 07:18 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

thank you, I really appreciate your information!



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