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Possible Granulosa Cell tumor? Weird hormone levels?

Equine-Reproduction.com Bulletin Board » General Mare Questions - Volume 3 » Possible Granulosa Cell tumor? Weird hormone levels? « Previous Next »


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Anna Royar
Neonate
Username: Macanddyna

Post Number: 1
Registered: 11-2011
Posted on Friday, November 04, 2011 - 11:38 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hey There! This is my first post here... and on boy do I have questions!
So, for some background, my 13 year old paint mare went into crazy heats this summer. Couldn't focus for more than 5 seconds, screamy, angry, make everyone miserable heats. She was not aggressive towards other horses, then again she NEVER is. We put her on depo and she really settled down. Then we moved barns. The depo seemed to work for shorter and shorter times until we stopped it in late September. At this new barn her heats aren't so raging but she seems to be hormonal more of the time and *seems* to have various soreness/lameness issues when ovulating.
I had a reproductive exam done and her ovaries are not enlarged and didn't show any abnormalities, her uterus was fine, everything checked out just fine. We got a hormone panel done and this is what we have so far, as emailed to me by my vet:

"The level of testosterone was 99.9 (normal 20-45)
Inhibin was low 0.01 (normal 0.1 - 0.7)
Progesterone is still pending.

Interpretation was that results may indicate a granulosa cell tumor.

Once final report is in I will let you know."

It seems like it's sort of weird and borderline for a that type of tumor (don't they usually have high inhibin? Testosterone over 100?) but I don't really know anything. Anyone here have any ideas what might be going on with my girl?
 

Jos
Board Administrator
Username: Admin

Post Number: 3424
Registered: 10-1999
Posted on Sunday, November 06, 2011 - 10:32 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Morganti et. al. discussed this phenomena at the 2010 AAEP Convention (Morganti M., Vico A.E., Ball B.A.; (2010) Stallion-Like Behavior in Mares: What Is the Role of the Adrenal Glands?; Proc AAEP (56)314).

In view of the low Inhibin levels and lack of ovarian enlargement, it is unlikely that you are seeing a GCT, but most probably you are seeing an elevation of Testosterone (and associated behaviour) brought about by the action of the adrenal glands. While there was no treatment identified or suggested by Morganti, I might feel inclined to attempt progestin therapy and evaluate the effects if it were my own mare. It would not be likely to impact the actual adrenal production, but it possibly may affect behaviour. Nothing ventured, nothing gained...!!! :-)



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Further, although we have the greatest respect for the posters offering assistance here, you are advised to seek a consultation with your veterinarian prior to using information obtained from this board if it is of a veterinary nature.

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