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Biopsy IIA

Equine-Reproduction.com Bulletin Board » Breeding Problem Mares - Volume 1 » Biopsy IIA « Previous Next »


Author Message
 

S Owens
Neonate
Username: Slowens

Post Number: 4
Registered: 03-2005
Posted on Monday, April 03, 2006 - 03:32 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I recently performed a breeding soundness pre-purchase examination on a 4 year old, healthy maiden mare. External conformation OK (slightly sunken in, not significant). Ultrasound revealed follicular activity bilaterally, relaxed cervix, slightly edematous uterus (all consistent with late estrus). Cytology revealed no abnormalities. Therefore I was expecting a Category I biopsy. However, the pathologist report came back with IIA, citing lymphocytic endometritis. No significant periglandular fibrosis, but "lymphocytes lightly but nearly diffusely infiltrating the lamina propria with tendency to concentrate in the stratum compactum or occ. to surround glands in the deeper lamina propria". Sorry long entry, but any thoughts as to whether this may cause significant decrease in ability to carry a full term foal, or any experience in follow up on a biopsy such as this would be greatly appreciated.
 

Jos
Board Administrator
Username: Jos

Post Number: 10557
Registered: 10-1999
Posted on Monday, April 03, 2006 - 04:07 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Did you run a culture to find out what the causative agent was?

IIA carries a 50-80% chance of a live foal. If you find out what is causing the endometritis and treat it, then you'll increase your chances.
 

S Owens
Neonate
Username: Slowens

Post Number: 5
Registered: 03-2005
Posted on Monday, April 03, 2006 - 06:01 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Cytology showed no pathogens, biopsy showed only lymphocytes (no neutrophils or macrophages) and after 4 days the culture was negative. So it looks like at this point there isn't exactly anything to treat.
 

Jos
Board Administrator
Username: Jos

Post Number: 10559
Registered: 10-1999
Posted on Monday, April 03, 2006 - 08:27 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I might feel inclined to try another biopsy, but taken during diestrus. There is something causing the endometritis, and one has to wonder if the response being seen is because the mare was in estrus at the time of sampling.



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