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Cystorelin???? ANYONE USED IT BEFORE?

Equine-Reproduction.com Bulletin Board » Breeding Problem Mares - Volume 1 » Cystorelin???? ANYONE USED IT BEFORE? « Previous Next »


Author Message
 

Amy C.
Neonate
Username: Amyd_dawn

Post Number: 10
Registered: 07-2005
Posted on Wednesday, August 17, 2005 - 03:57 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Has anyone in here given their horse Cystorelin to help get their horse bred and had a good success? I look up information on it and it says that it is mainly used for cattle production. I am new at this because I have never had any problem before with getting my mare bred. can someone please respond?
Thanks
 

Jos
Board Administrator
Username: Jos

Post Number: 10272
Registered: 10-1999
Posted on Thursday, August 18, 2005 - 05:49 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Cystorelin is a form of GnRH. When used in the equine (which is not that common) it is generally used for inducing ovulation or assisting in follicular development. Multiple daily doses are most commonly used, as a single dose (unlike hCG for example) is not usually sufficient.
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 11
Registered: 07-2005
Posted on Thursday, August 18, 2005 - 08:06 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

What is the most common to use on a horse? Is there any percentage rate of the Cystorelin working on a horse or does it just depend on the horse? How many doses does it usually take to make it sufficient? I would really like to know so that I can bring options up to my vet. Thanks for the response Jos!
 

Jos
Board Administrator
Username: Jos

Post Number: 10275
Registered: 10-1999
Posted on Thursday, August 18, 2005 - 10:11 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

What is your intended use aiming to achieve?
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 12
Registered: 07-2005
Posted on Thursday, August 18, 2005 - 10:49 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I have been trying to get my mare bred. We have bred her the past 3 years, in the springtime but have not succeeded. All of her previous colts have been late colts so now we are trying for another late colt. I have talked to my vet about her not taking and he had mentioned that next spring we can do a uterine biopsy to see exactly is going on. Well I had changed her feed which had caused her to bag down and start lactating and the vet had said that she has started to produce more estrogen more than likely caused from the feed, so we should try to get her bred her next cycle. He had given me a shot of Cystorelin to help boost her heat cycle. The breeder has to administer the injection on her second day of cycling and cannot breed her for 24-48 hours after the injection has been given. I guess I am just wondering if there is a good chance of a good outcome or at another dead end? I would like more advice about different shots or other options of getting her to foal one more time if Cystorelin is not commonly used.
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 13
Registered: 07-2005
Posted on Thursday, August 18, 2005 - 10:52 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

I guess also what I want to know, if one dose is not sufficient, then how many doses would it take on a horse? Or is there something better to use?
 

Jos
Board Administrator
Username: Jos

Post Number: 10276
Registered: 10-1999
Posted on Thursday, August 18, 2005 - 10:57 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

In the absence of a confirmed diagnosis of a problem - which it appears is where you are at - I would not expect Cystorelin use to be particularly beneficial. If you are identifying follicular development and timely ovulation, then use of GnRH seems a redundancy. It may be that your vet is seeing or aware of something else that [s]he is using it for though, so perhaps you should ask them for more details behind it's use. Cystorelin is not particularly cheap and using it in the absence of a confirmed diagnostic seems somewhat of an expensive "shotgun" approach...

Are you working with a reproduction specialist veterinarian (a Board-certified Theriogenologist)? Use of such a specialist may be a positive move if you are not.
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 14
Registered: 07-2005
Posted on Thursday, August 18, 2005 - 11:12 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thank you for the advice! I am at the point that if this does not work, I give up. She is 19 years old and such a good mare, I wanted one last baby out of her that will NOT be sold. My vet has mentioned that there shouldn't be anything wrong because she is still very regular in her cycles just like clock work. He has said that the Cystorelin will "boost" her cycle. I just wanted your opinion. Thank you!
 

Jos
Board Administrator
Username: Jos

Post Number: 10277
Registered: 10-1999
Posted on Thursday, August 18, 2005 - 11:16 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

If she's 19 I would check out the article about using oxytocin in the broodmare with delayed uterine clearance ("DUC"). DUC is an extremely common problem in older mares, and we have had excellent success using the oxytocin - plus which oxytocin is cheap!
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 15
Registered: 07-2005
Posted on Thursday, August 18, 2005 - 11:21 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Thank you very much!!!
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 16
Registered: 07-2005
Posted on Wednesday, August 24, 2005 - 10:57 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Well my mare went into cycle about a week and a half early and the breeder gave her the shot of Cystorelin today and she's already bred twice. She is extremely "milky" from her heat cycle and has bagged down and lactating again. Could this be a good sign that she might have a better chance of taking? The breeders says that he guarantees that she will for sure take this time. Does anyone have any thoughts on this???
 

Jos
Board Administrator
Username: Jos

Post Number: 10280
Registered: 10-1999
Posted on Thursday, August 25, 2005 - 12:44 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

The indications you comment upon bear no correlation to an increased fertility level, and any breeder that claims a guarantee of pregnancy before or during the breeding process is someone to have as a good friend if their results match their claims... I sure wouldn't want to make that claim! :-)

Having said that, "never say never".... :-)
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 17
Registered: 07-2005
Posted on Thursday, August 25, 2005 - 07:46 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

LOL I agree with you!!! However could it just be that she is a "late bloomer" where she has NEVER had a spring colt? They ALL have been late July and August babies. It has just been the last few years that we have tried to get spring colts and never succeeded.
 

Jos
Board Administrator
Username: Jos

Post Number: 10282
Registered: 10-1999
Posted on Thursday, August 25, 2005 - 11:44 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Could be...
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 18
Registered: 07-2005
Posted on Friday, September 02, 2005 - 11:14 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

What is the number of days that a mare breeds for? Last time I took her to get her bred she bred for 8 days and didn't take, now this time, she bred for only 6 days. Or I guess what I should be asking is how long does a normal heat cycle last and do the mares breed throughout their whole heat cycle or will they stop breeding once they are bred? The suspense of whether or not took is absolutelly KILLING ME!!!!
 

Jos
Board Administrator
Username: Jos

Post Number: 10295
Registered: 10-1999
Posted on Saturday, September 03, 2005 - 02:22 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

The average number of days for estrus ("heat") is between 5-7 days, but that is an average and there is a distinct mare variation, so being outside that time frame is not unusual. In the height of the breeding season (the natural breeding season, not the human imposed one that starts in February in the northern hemisphere), many mares will have a shorter estrus phase than they will earlier in the season. I believe this is what you are seeing.

Mares will accept the stallion throughout the entire estrus phase - they do not stop accepting the stallion once fertilization has occured (note that the term "bred" in fact indicates the physical act, not the pregnancy status).

There is no way that you are going to be able to determine pregnancy status until she is ultrasounded about 15 days after the ovulation.
 

Amy C.
Nursing Foal
Username: Amyd_dawn

Post Number: 19
Registered: 07-2005
Posted on Sunday, September 04, 2005 - 04:22 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

UGH! This is going to drive me totally insane! Thank you for explaining that to me Jos!!!
 

Amy C.
Weanling
Username: Amyd_dawn

Post Number: 23
Registered: 07-2005
Posted on Saturday, September 24, 2005 - 12:41 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

well exactly one month ago is when we bred my mare and so far so good. We have her between two studs to try to tease her a little bit to see if she will come into cycle. I am taking her tomorrow to have her ultrasounded (keep fingers crossed). I guess I will let you know if the cystorelin shot worked or not.
 

Jos
Board Administrator
Username: Jos

Post Number: 10319
Registered: 10-1999
Posted on Saturday, September 24, 2005 - 12:56 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Why did you wait a month before having her pregnancy checked? Twins if they are present are more easily and successfully dealt with early.

Good luck.
 

Amy C.
Weanling
Username: Amyd_dawn

Post Number: 24
Registered: 07-2005
Posted on Saturday, September 24, 2005 - 11:10 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Well, everything is good!!! She is bred and with only one baby, however there was a spot on the opposite side and the vet thinks that maybe she might have had twins but absorbed one. But the fetus has a good strong heart beat and everything looks good. I take her back in 4 months to get checked again.



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