Posted on Thursday, September 07, 2000 - 11:47 am:
When treating a mare post breeding who has a problem with delayed uterine clearance, you advise giving the oxytocin IM....this probably slows the absorption of the drug as opposed to SQ? Can you explain!! Thanks ! Linda
Jos
Posted on Thursday, September 07, 2000 - 05:30 pm:
Actually I recommend using the Oxytocin IM rather than IV, not SQ (for those readers who may not be familiar with the definitions of the abbreviations, they are intramuscular (IM); intravenous (IV); subcutaneous (SQ)).
The IV route will give a very rapid rush, whereas the IM route slows it slightly. In either case, it will still be cleared fairly rapidly (the half-life of Oxytocin is 12 minutes), and this is why some clinicians are using the Prostaglandin analogue Cloprostenol, which has a similar involutory action on the uterus, but will remain active over a longer period.
what are the results then (if any) when oxytocin is used SQ for delayed clearance? Does this route of administration (SQ) decrease the effectiveness of the drug? Is the drug Cloprosternol new for vets to use? Would this be the drug of choice to reach for when treating a older mare with delayed clearance? it just seems that the drug reached for is the oxytocin...without question!! Thanks! Linda
Jos
Posted on Friday, September 08, 2000 - 09:29 am:
I am not aware of anyone who has intentionally used Oxytocin SQ. It's recommended route of administration is IM or IV. SQ would I believe result in a less effective response.
Cloprostenol has been around for years, it is actually a cattle drug, that is used in the same manner as "Lutalyse" is in horses - i.e. to induce estrus by destroying the CL. It is a synthetic prostaglandin. It has also been used for many years in horses in the place of "Lutalyse" or other prostaglandin products, as it is less inclined to elicit the dramatic sweating and colic-like response that prostaglandin does. Cloprosenol is marketed under the trade name of "Estrumate".
It has been noted by some that Cloprostenol will cause involution of the uterus, just as prostaglandin products will (you could also use prostaglandin instead of Oxytocin). The reason that Oxytocin tends to be reached for first is that it is the hormone that causes the involution naturally (for example it has a large part to play in the foaling process).
I would feel comfortable using either Oxytocin or Cloprostenol when following my 6 hour protocol. If I was not going to give as many doses as that protocol calls for, I may be inclined to use the Cloprostenol or Prostaglandin (both of which can be used SQ if you so desire!)
A good friend of mine would like me to ask for your reccommended use of oxytocin for pre and post breeding. She has used the drug in this manner before, but would like to get the maximum benefit, without overdosing in some way.
Thanks, Marsha
Jos
Posted on Monday, April 02, 2001 - 12:15 am:
There is an article that deals with the use of oxytocin pre- and post-breeding in depth on this site available by "clicking" here.
Hope it helps.
Julie Englund
Posted on Thursday, April 05, 2001 - 01:58 pm:
Hello,I read your article on oxytocin, thank you for all of the good information. I didn't find any specifics on a pre-breeding regimen. Any additional information in this area would be greatly appreciated. Thank you again, Julie
Jos
Posted on Thursday, April 05, 2001 - 09:48 pm:
Try 10 iu 2 times daily for the two days prior to breeding, or as your veterinarian recommends. Note that pre-breeding use is not indicated unless uterine fluid is detected.
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