I have a 13 year old maiden mare with a Candida uterine infection I intend to breed this spring. I am just wondering if anyone has had any luck with one day therapy of flushing the uterus with sterile saline followed by lufenuron mixed with sterile saline, as it is supposed to stay in the uterus for 28 days, with the hopes of breeding on the next cycle. I would like to hear of any other treatment regimens that have been successful as well. Thanks
Just as an update to the previous post, we flushed the mare with 1500ml of sterile saline and then infused 1200mg of Lufenuron dissolved in 60ml of sterile saline in to her uterus. I held the cervix tight for about 10 minutes following the infusion. She was in diestrus at the time.
We bred on the next cycle, she came up open 2 weeks later and I re-cultured and she was loaded with Candida. So our experience was not too great with Lufenuron.
The mare has been previously treated with 4 days acetic acid infusion and 4 days sterile saline on different occasions, all to no avail. I think she must just be a highly susceptible mare without much of a future in the breeding business.
Did you also thoroughly rinse out (lavage) the vagina and clitoral fossa with the Lufenuron? If you didn't, then it is probable that the pathogen remained present in the reproductive tract and simply reinfected the uterus.
It's necessary to make sure the entire reproductive tract is treated with Lufenuron in order to achieve a higher success rate. Treatment of the uterus alone is insufficient.
Thats a good point you bring up. I got some of the Lufenuron in the vagina but I wouldn't say that I thoroughly lavaged it or bathed the tissue in the drug, so that definitely is a possibility.
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