Jos, I have two 22 year old mares. One a shire weighs 1700lbs the other a shetland weights 350. Would the 10iu dose be different for these mares as compared to saddlehorse size?
Posted on Sunday, June 23, 2002 - 09:10 pm:
The research by Dr. LeBlanc was conducted on "average" size light horses between 800 and 1100 lbs, so as far as I am aware, there has not been any evaluation done on different sized animals outside those parameters.
I would feel inclined to marginally reduce the dosage for the smaller animal - although it is worth considering that if the pony is half the size of the sudy animals, it is still receiving dosage within the safe parameter, although one then gets back to the question about the lower dose being more effective for systematic uterine clearance pre-ovulation.
It is also probable that a marginal increase would be merited for the larger horse, although I would not probably be looking at doubling the dosage.
Oxytocin is active in the body in a very short period of time - a little over 60 seconds - and it is dissipated in an hour, so the action will be fast-hitting and short lived regardless (up to a point) of the dose size.
An interesting question and one worthy of further research - if you see differing results I would be interested to hear.
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