What EXACTLY does Betadine do in the uterus, what is the medical rationale for using it vs. DMSO.
I have a mare whose last two uterine biopsies were graded 2B (minimal scarring, chronic active inflammation). We have used saline lavages pre- and post-breeding AI, no foal. She has very short cyles (2-3 days) and ovulates on 20-30 mm follicles. We have also tried Oxytocin post AI every 6 hours. No foal after 3 tries (this mare was not really pooling fluid so it was decided not to use oxytocin more frequently). I have decided to quit for the season but one Repro vet I consulted suggested a Betadine flush to try to imrove the condition of this mares uterus. I spoke to another vet, who runs a reputative Repro center and he said using Betadine is absolutely outrageous and could cause damage to the uterus, he suggested DMSO (he also said only God could improve a 2B uterus and that anyone who says they can change a 2B to a 1B is a fool). I am very confused and a little annoyed that two Repro vets could have such divergent opinions on Betadine. I asked a third vet (not a repro specialist) who agreed that Betadine would not be her choice and wondered why anyone would think of putting it into a mare's uterus (said is was very caustic).
If I left this mare alone for the winter and do another biopsy in the spring will her uterine condition deteriorate? or should I treat her now and then leave her for the winter and try again next year?
Posted on Monday, July 23, 2001 - 11:18 am:
If you go to the topic board, and look at the postings, you will find a few discussions on this topic. There are also sugested links to view.
All these opinions can make you wonder! Keep asking questions and you will eventually have the information that you need.
Posted on Saturday, January 05, 2002 - 09:17 pm:
Okies... A FEW things that I know about DMSO:
* It can cause cancer and/or birth defects in animals and humans.
* It can transport NE dirt or dyes into the horse's skin while being applied
* it is made from wood pulp
* It has no proven use, and can be used from horses to a cleaner
* It is NOT made in a medical safe facility usually, so can have contaminents in it
* When used CORRECTLY and made in an approved facility it can be used to transport medicine into the cells
THats a little bit I found out from research on the web.
Posted on Monday, January 14, 2002 - 04:00 pm:
Just a quick update. I had the mare with one ovary and a 2B uterus. I was considering treatment but prior to doing anything I had this mare re-biopsied by vet #3 and here are the results: Biopsy date was 9/01 HISTORY: Has had one foal (1997 or 1998). GCT removed 1999. PHYSICAL FINDINGS: L neg. R ovary has CL UTERINE CULTURE: negative HISTOLOGIC DESCRIPTION: 6 histologic sections. No PMNs in uterine lumen; luminal epithelium is cuboidal to low columnar. The uterine glands are very inactive (seasonal anestrus or other form of suppression). Gland density is adequate; no signs of periglandular fibrosis. DIAGNOSIS: 1. Normal, anestrus-appearing endometrium. PROSNOSTIC CATEGORY: 1 RECOMMENDATION: No pathology noted in this endometrium. However the uterine glands are very inactive which suggests the mare is already in sesaonal atrophy (quite early), or the uterine glands are under some level of suppression. No treatment is indicated at this time.
Is it unusual for a mare to have this kind of biopsy result after 2 previous biopsies showed 2B!! I am perplexed, but have to say that Vet #3 is a Repro-only guy, does over 500 equine embryo transfers per year. So I am encouraged by this result. No DMSO NO Betadine! I am relieved, really didn't want to do anything drastic.
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