My mare has had two foals, but it has been taking her about 2-3 yrs to get pregnant between foals. She has a history of absorbing the pregnancy early. She was recently diagnosed with a grade 2B uterous. The vet said it had to do with her glands and suggested we flush her when she comes back in season. Can you please expalin a grade "2 B". And is this the best treatment for her situation, or do you need more information? Thank you for any insight you can give me. Shelly
Hello Shelly, Sorry I respond late but I've just read your message. A 2B endometrial biopsy grade means that your mare suffers of endometritis (inflammation of the endometrium, the mucosal layer of the uterus),with a moderate and diffuse infiltration by inflammatory cells, associated with low number of foci of periglandular fibrosis. It's also possible to notice the presence of hyperplasia (an increase in the number of cells) of the glandular epithelium. It's known that the foaling rate averages 10 to 50 % in this grade. That's low, indeed. But we can explain that, by the fact that the fibrosis and the persistent inflammation causes a deleterious environnement for the embryo which can not establish correctly and finally dies. Such mares are considered to be susceptible to uterine infections due to their unability to completely clear their uterus from micro-organisms and inflammatory fluids, condition that makes those mares suffer of persistent endometritis. This endometritis can occur even after an artificial insemination when the semen is not mixed with antimicrobials. Your mare should be bred artificially, using the "Minimum Contamination Technique" which consists on the intra-uterine administration of a semen diluent containing antibiotics, immediately before natural or artificial breeding. Discuss this with your vet. There are some kinds of treatments aiming to stimulate or to enhance the uterine defense mechanism against infection. Some of these are:
* intra-uterine infusion of plasma (homologous ro heterologous)during estrus. Blood should be collected on heparin or citrate but not on E.D.T.A.
* intra-uterine infusion of blood collected on heparin. This blood can be mixed with killed culture of Candida albicans (a yeast)
* intra-uterine infusion of equine colostrum
* immunisation with Propionibacterium acnes (a micro-organism) via intravenous injection
I hope I helped you a little. So tell me if you're satisfied of my response or not. Looking forward to hear from you. I'm ready to help you for any problem you face concerning equine reproduction. So contact me anytime you need. Good luck Shelly
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