I got some hCG from one of my local vets. He had it there in the fridge but has never used it before for equine. Its brand name is Novarel and there are two bottles one dry and one wet. It says 10,000 USP units, Two-Vial Set, 10mL. I think he had once used it for dogs (he's not into equine repro). Would this type of hCG be ok to use to for ovulation in mares? My next question is by mixing it at 10mL and I only need to use 2mL to get 2,000 UI can the rest of it be kept after it's mixed, and how long? Also should this be given IV or IM? I'm used to seeing my equine vet give it IV but it says on the box for IM use only. It says on the box (Chorionic Gonadotropin for Injection, USP) With Bacteriostatic Water for Injection, USP as Diluent. Ferring Pharmaceuticals
Jos Posted From: 188.8.131.52
Posted on Friday, August 06, 2004 - 09:21 pm:
I am not familiar with that particular brand of hCG, but suspect it may be for human use. As I am not familiar with that brand, I cannot say with certainty if it is suitable for use in the equine - your vet should be able to establish that information for you.
The generally recommended dosage for mares to stimulate ovulation is anywhere between 1,500 and 3,300 International Units. Dosing in excess of 5,000 units may retard or supress ovulation.
The protocol for mixing is to add the water to the powder, and shake until dissolved. Note that although you are adding 10-ml, the final volume may be slightly more than that as the powder may add to the volume. We will reconsititute, then draw all the liquid back into a syringe to establish the volume, and then decide how much volume per dose after that.
It can be given either IM or IV, but anecodotal evidence suggests that IV results in fewer reactions - which are rare anyway.
Storage time after reconstituting is limited, and it is best to draw it off into individual dose syringes and then freeze those rather that refrigerating. If frozen, I prefer to use it within the same breeding season.
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