Posted on Wednesday, February 27, 2008 - 12:58 pm:
It is only comparatively recently that the CRISP3 (or in particular polymorphisms related to it) has been confirmed as having fertility implications. In 2005 at the ISSR it was observed that "the high expression of CRISP3 suggests that this protein may have an important function in equine reproduction" (Leeb et. al. Genetic markers for stallion fertility - lessons from humans and mice), but by 2007 in research done by Leeb et. al. at Celle with the Hanoverian stallions (A polymorphism within the equine CRISP3 gene is associated with stallion fertility in Hanoverian warmblood horses the link is more clearly defined:
Stallions heterozygous for the CRISP3 c.+622G>A SNP had lower fertility than homozygous stallions (P = 0.0234). The pregnancy rate per cycle in these stallions was estimated to be ~7% lower than in stallions homozygous at this position.
I think therefore that although there is promise in the identification of fertility and fertility issues related to the CRISPs, there is still room for more research to confirm the more clearly defined link, and therefore the preparation of a commercial genetic test.
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