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CRISP3 snp test

Equine-Reproduction.com Bulletin Board » Equine Genetics » CRISP3 snp test « Previous Next »


Author Message
 

Jamie Anderson
Neonate
Username: Jamiea

Post Number: 1
Registered: 02-2008
Posted on Saturday, February 23, 2008 - 08:07 am:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

Hi everyone,

I read that CRISP3 (a stallion seminal plasma protein) can affect stallion fertility. Is anyone offering a gene test for this SNP, and if not, why not and is it possible to do?

Cheers

Jamie
 

Jos
Board Administrator
Username: Admin

Post Number: 1731
Registered: 10-1999
Posted on Wednesday, February 27, 2008 - 12:58 pm:   Edit Post Delete Post    Move Post (Moderator/Admin Only)

It is only comparatively recently that the CRISP3 (or in particular polymorphisms related to it) has been confirmed as having fertility implications. In 2005 at the ISSR it was observed that "the high expression of CRISP3 suggests that this protein may have an important function in equine reproduction" (Leeb et. al. Genetic markers for stallion fertility - lessons from humans and mice), but by 2007 in research done by Leeb et. al. at Celle with the Hanoverian stallions (A polymorphism within the equine CRISP3 gene is associated with stallion fertility in Hanoverian warmblood horses the link is more clearly defined:

Stallions heterozygous for the CRISP3 c.+622G>A SNP had lower fertility than homozygous stallions (P = 0.0234). The pregnancy rate per cycle in these stallions was estimated to be ~7% lower than in stallions homozygous at this position.

I think therefore that although there is promise in the identification of fertility and fertility issues related to the CRISPs, there is still room for more research to confirm the more clearly defined link, and therefore the preparation of a commercial genetic test.



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