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micro dosing

Discuss tips and tricks used in live cover and AI situations.

Moderator: Jos

micro dosing

Postby sparkskaren » Mon Jul 30, 2012 2:33 am

i had a vet out on friday to PGF2α one of my mares when i asked if we could micro dose her as it is nicer for her. he had never heard of doing this. he did sort of do it so hoping it works. she should have had 2ml in one dose he gave her 5ml on the first day and i gave her 0.3ml on the second day. so hoping it still works. is there an article anywhere about micro dosing that i can print of and give to him when he comes back tomorrow to re-scan? thanks
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Re: micro dosing

Postby sparkskaren » Mon Jul 30, 2012 2:34 am

sorry that should have said 0.5ml on the first day
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Re: micro dosing

Postby Jos » Mon Jul 30, 2012 2:44 pm

There was initial work by Burns et. al. that investigated the effects of micro-dosing with PGF2α at the BAI HUI point, that work was done in the late 1990s I think.

Then in 2001 Nie et. al. investigated the effects of microdosing at both the BAI HUI point and elsewhere and published the findings in The American Journal of Veterinary Research. The abstract of that work can be viewed in PubMed in the paper entitled Luteal and clinical response following administration of dinoprost tromethamine or cloprostenol at standard intramuscular sites or at the lumbosacral acupuncture point in mares.

In 2002 Irvine et. al. continued the investigation and presented a paper in The Equine Veterinary Journal, the abstract of which can be viewed on PubMed in the paper entitled Effectiveness of a two-dose regimen of prostaglandin administration in inducing luteolysis without adverse side effects in mares.

The full papers can be viewed on PubMed if your vet has full access, or in the Journals named if they subscribe to the publications.

There were also 2 papers presented at the International Symposium on Equine Reproduction in 2002, which if your vet has access to a copy of the proceedings can also be reviewed. One of those was the paper (or a similar paper) by Nie.

As you will note, this is not exactly new research, being 10+ years old... :-(
We're always happy to try and help, but don't forget to check the articles section
of the website too, which has a search engine to help you look for answers!
:)
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